The 2026 ACC/AHA Dyslipidemia Guideline introduces five major changes: a new risk calculator (PREVENT replaces Pooled Cohort Equations), explicit LDL targets reinstated (below 55 mg/dL for highest-risk patients), universal Lp(a) testing for every adult, formal Class 3 (No Benefit) ratings for dietary supplements, and CAC score tiers tied directly to LDL goals. This article explains [...]