EP42: The Critical Age of Aging Acceleration and What You Can Do About It!

Guest: Dr. Nayan Patel 

Your body is already producing the most powerful antioxidant on the planet, and it starts running out before you turn 30.

On this episode of Own Your Heart Health, holistic cardiologist Dr. Regina Druz sits down with Dr. Nayan Patel, a doctor of pharmacy who has spent 27 years researching a single molecule, glutathione. His findings challenge nearly everything the wellness industry has told us about antioxidants, longevity, and how aging actually works.

Dr. Patel explains that oxidative stress is the number one driver of chronic disease and early death worldwide. It begins quietly, around age 28 or 29, when glutathione levels start to fall and cellular damage begins compounding faster than the body can keep up. Most people are decades behind by the time they start paying attention.

The supplement aisle is not the answer. Dr. Patel breaks down why popular antioxidants like vitamin C and CoQ10 are far less powerful than believed, and why even intravenous glutathione clears the bloodstream within minutes. Real health improvement requires getting glutathione inside the cell, across the cell membranes, where it can do its two core jobs of neutralizing free radicals and supporting liver detoxification.

After years of research, Dr. Patel developed a topical delivery method that does exactly that. A recent clinical trial showed oxidative stress markers dropping to near zero within one hour in every single participant.

But both Dr. Druz and Dr. Patel are clear that no supplement works without the foundation. Cutting alcohol, reducing toxic exposures, and eating a cysteine-rich diet are what sustain your glutathione levels and protect your lifespan long term.

Your body was built to heal itself. This episode shows you how to let it.

🎬 Watch on YouTube: This episode is now available on the Own Your Heart Health YouTube channel. Subscribe to be notified.

Episode Chapters

[00:00]	Introduction to Oxidative Stress and Longevity with Dr. Nayan Patel
[02:39]	From Aerospace Engineering to Glutathione Research
[07:41]	Why Oxidative Stress Is the Number One Cause of Death
[10:52]	Why Aging Begins at 28 and What You Can Do About It
[23:44]	Why Glutathione Outperforms Every Other Antioxidant
[28:17]	The Real Role of Vitamin C and How It Recycles Glutathione
[32:54]	Lifestyle and Diet Changes That Protect Glutathione Levels
[50:05]	How Topical Glutathione Crosses Cell Membranes
[54:40]	Clinical Trial Results Showing Glutathione’s Impact on Immune Function
[1:00:06]	How to Get Dr. Patel’s Glutathione Product and Learn More

Podcast Transcript

[00:02] Dr. Regina Druz

Welcome to Own Your Heart Health. I’m Dr. Regina Druz, your holistic cardiologist. This week, we will dive into common heart health concerns, uncovering root causes, and unpacking scientific discoveries and controversies. The information provided does not constitute medical advice. Please contact your health care practitioner before making any changes that may impact your health.

Well, hello everyone. And what do you know? We are at the Vernal Equinox. As I learned today, this is the day when spring officially begins and Earth, our planet, is an equipoise. We get just as much light as we get the night time. So 12 hours and 12 hours, we’re right in the middle, we achieve the balance. And so today I have a guest who spent his lifetime refining, finding and bringing us an idea of what it means to be balanced with regards to health optimization and longevity. And he is a doctor, but he’s a doctor of pharmacy. And, you know, a very small ⁓ sort of tidbit for all of you is that pharmacists are our secret weapon. When we as physicians don’t know our stuff, we call the pharmacists, they’re like ghostbusters because they can come and they can fix everything. So I present to you Dr. Nayan Patel, who has carved a very unique path in medicine, in pharmacology, of course. And we’re going to talk about some of the most exciting topics that you already heard in the show today, but certainly hormonal optimization and my favorite, oxidative stress and detoxification. Welcome to the show, Nayan.

Dr. Nayan Patel (01:51)

Thank you for having me. What a long introduction, but I was listening to it and I this is very unique and I appreciate the equipos we are in today because at end of the day, all my message is going to be the same way. I hey, how can we do less for our body and recreate this balance that has been there for millions of years? And we’re trying to play God by using medications and interventions to extend life and longevity, in reality, it’s all about working with the environment and see what that needs. So thank you for reminding me for about an hour.

Dr. Regina Druz (02:30)

Exactly. And so, you know, I’m going to ask you the same question I ask all of my guests. How did you grow up to be who you are today? Give us your story.

Dr. Nayan Patel (02:39)

my goodness, this was, it is not a juicy one, but I was actually in aerospace engineering. ⁓

Dr. Regina Druz (02:47)

It is pretty juicy when somebody comes from another industry.

Dr. Nayan Patel (02:52)

And the thing is, if you think about it back in the, 35 years ago, 37 years ago, the only jobs or only chances you had was working with the government because there was, we didn’t have SpaceX like we have today. I wish Elon Musk was there and had that space thing available 35, 40 years ago, I would be a whole different person today. the thing is, I’m glad that he was not there because they gave me a chance to explore a new world in pharmacy.

And the world began in 1996 when I graduated from the Pharmacy School. And I thought that I can change the world with medications, knowledge that I have and help people heal. I quickly realized that all the medications, everything we got was only going to maintain the problem, never going to solve the problem. And hence we are here today talking because I chose a route that I thought is going to give us an opportunity.

to actually heal ourselves instead of just maintaining the problems that we accumulate as we grow older. And so I started my career as a company pharmacist doing hormone optimizations and hormone balancing. And from that early on to 30 plus years ago, I got a whole new appreciation of people that were actually not just looking for just hormone optimization, but looking at that as a stepping stone towards longevity.

So I started training doctors and talking to CEOs and all the high-networked individuals and all those people that are looking for say, this is great. I want my good hormones, but you got something for mental aging. You got something for some longevity. mean, you know, thing is I’m dating myself now over here. But so that my path has also, you know what? I’m a farmer. I’m sure I can figure things out. You know, it was, I had no idea that I was to spend 27 years of my life just working on just one molecule, which is glyothiol.

But here we today talking about glutathione and what I have accomplished in my 27 years of career, not just as company pharmacist alone, but using that knowledge to come to this stage to talk about glutathione as well.

Dr. Regina Druz (04:59)

Amazing. you know, this is, I always feel so inspired when I meet people like you and, you know, there have been so many great guests on the show is because often, you know, we as adults, right, we start to doubt ourselves. We start to kind of go and run in all different directions because let’s face it, know, longevity as a concept, it’s not really well defined. Yes, there’s a lot of good research coming around. The research have become much more rigorous.

and intense and artificial intelligence opened the way for a lot of things that we could potentially gather and find these patterns. But let’s face it, most adults, whether they’re patients or not, if you get a regular person off the street and maybe I’ll do it as an experiment, then you’ll ask them, what is longevity for you? You’re probably going to get 10,000 different answers, right? If you ask 10,000 people. But you discovered that

one of the very fundamental pathways in longevity, and it’s one of the hallmarks of aging, of course, is the one that has to do with the oxidative stress. So, you know, this is a concept that I find that even as a physician, I have to spend a little bit of time trying to explain it to my patients. So I want to hear from a pharmacist perspective, you know, like your career of nearly 30 years, what is oxidative stress and why should we care?

Dr. Nayan Patel (06:25)

So, before I answer the question, I wanna mention people about one more thing about longevity, because longevity, most people that I talk to, longevity is that, I wanna live longer. And so, the only way you can live longer is guess what, if you don’t die. And so, I mean, it’s a very rudimentary answer, but the thing is, we’ll look at it. If I can prevent car accident, and if I can extend your life, is…

not driving every single day and sitting in your home, addressing with longevity? No, because it’s not living. You are stuck. Yeah, you won’t die of a car accident, but at least you die of some other causes. So if you think about longevity, ⁓ the only drug that has ever shown to increase lifespan in the last hundred plus years, it was penicillin. Because a hundred years ago, people were dying off of infections. And so because of that drug ⁓ or that

concept of sanitary conditions about in surgeries and whatever you do everything is sanitized now and people live longer but today we will not take ⁓ penicillin to external life there’s no way right

Dr. Regina Druz (07:35)

It’s not a synolytic, right. Exactly. It’s not a synolytic, which is, go ahead.

Dr. Nayan Patel (07:41)

So today, the number one cause of death is oxidative stress. It is linked to thousands of diseases. So if we can conquer oxidative stress, we’ll come to a new horizon in the near future that, okay, we conquer oxidative stress now, we extend life by another 15, 20, 30 years, whatever we can get, I don’t know, we can get five years, I don’t know how much we can get extended of lifespan, but you’ll come to a new horizon and from there we can see what else will cause us to die.

So we keep on conquering this path as we go. So to me, oxidative stress, mean, oxidative stress is something that is a natural process. Every human being has an oxidative stress because without that extra stress in your body, your body actually crumbles up and die. So it is not good to have zero stress. You’re going to have a liberal stress, so the body always stays in a hyper alert. Oxidative stress, the word oxidative means what? Oxygen loving, right? We breathe oxygen every single day.

We, our body consumes oxygen. the only energy source we get. But what happens, the process of using the oxygen also creates something called ⁓ reactive oxygen species called ROS. And that’s the holy grail of what causes damage to the body. And if we want to give you an analogy, think about a nail. A nail that’s outside in the sun, in the water.

is gonna get started rusting. It doesn’t rust today, but within a few days it starts rusting. A small speckle comes over here, rusts, and if you don’t do anything about it, within a few weeks the whole thing will just crumble up into rust and the whole thing is gone. Then rusting, the process of rusting is what oxidative stress is to me. And so all I’m always thinking is that, my body is rusting from inside every single day. The rust is

Dr. Regina Druz (09:35)

Not a good image.

Dr. Nayan Patel (09:36)

Not a good event, but start at the-

Dr. Regina Druz (09:39)

But you did mention something very important, right? So we have to breathe oxygen because that’s how we survive. And reactive oxygen species, it does actually have a useful purpose because we use it to kill bacteria, to kill viruses, to kill the cells which are old sort of zombie cells that our body no longer needs, right? So we can’t be in this world without generating reactive oxygen species.

it’s or these ROSs, but when we generate too many of them and we can’t neutralize them, that’s where the problem starts, right? So remember how I started the show with all this balance. There has to be this equipoise, right? Between the useful stuff and the negative stuff. how does one, know, what are the processes in the body is sort of, what can one do to figure out, are they in that sort of good stress zone, right? They’re generating enough of those ROS’s and they’re destroying them just as quickly as they come up, know, so the job is done, but you know, there’s little damage or are they sort of ⁓ kind of progressing more down the damage path?

Dr. Nayan Patel (10:52)

So in my research, what we have found out is that about the age of 28, 29 is the first time there is a spike in the oxygen stress markers. That’s the first time you see in the epigenetic centers, the mutation is increasing, the body’s aging at a pace which is much faster than a normal aging pace. And people don’t think about 20, 29 is the…

is the starting point of aging process because at 20, 29, guess what? You’re invincible. You think that nothing’s gonna happen to you ever, right? And anything that happens to you, is because of I just got married, or because I just had a kid, or is it because I have a new job, or I change a house. People will blame the other environmental factors or other things that happens in their life from external sources is the reason why they’re not feeling good.

But in reality is that the very first time if you pay a close attention to your body is you start seeing changes in all these markers. And again, it’s not enough to do any treatments because you’re still within the range. You’re not out of the range yet.

Dr. Regina Druz (12:02)

You’re not sick. You’re not optimized. You’re just not optimal anymore. Right. So what are those markers that, know, and this is very interesting to me because I’ve been sort of diving into the longevity research and, know, people, humans, early humans, you know, even like at the dawn of our industrial revolution, a lot of people would sort of pass away in their mid thirties, right? Accidents, infections.

injuries. we, you know, but we cleared that hurdle because we took control of so many of those diseases. You know, we’re wearing seat belts and all of that sort of stuff happening, right? But now then we opened up the door to this aging phenomena and we’re learning that after 30,

That’s when aging starts to accelerate and then those sort of like different trajectories. In some people, this acceleration is very muted and in other people, it’s very sharp. I I met patients in their mid to early 30s with horrific coronary artery disease or heart failure. at the end of the day, that’s the ultimate expression of that oxidative stress of that aging process.

So what are these markers that you would be looking for, let’s say, in fairly, you know, sort of young adulthood, you know, if somebody says, hey, I don’t want, know, to rust on the inside, let me, let me take care of it now.

Dr. Nayan Patel (13:28)

So the thing is I have done so many blood tests. I’ve probably done thousands and thousands of blood tests for a lot of my patients and worked with the physicians all across the country. there’s a few markers that we looked for. One is the MDA, which is melanolaldehyde levels is what we measured. We measured the 4 H and E levels. We also measured 8 hydroxy, oxidative stress markers. We also looked at the oxyestral cholesterol markers, A for B levels. But again, these are all…

secondary markers. mean, the changes are already happening. And the thing is, for me is that do I want to see a change in those markers to do an action? Or do I want to assume that, this is the age things are to go crazy. So let me prevent what happened in the first place. And what you just said is absolutely correct because heart disease is still the number one cause of death.

in the world, right? And think about it, the heart doesn’t stop beating because it’s getting weaker. It stops beating because now it has a lot more, it has to exert a lot more force to just keep on going. And it starts with oxygen stress markers from early on. Late 20s starts from there and then onwards. And so whatever we can do to reduce oxygen stress, your heart can beat for that much longer.

And to me, that is the best thing that can happen to you because you can live with some of the organs not fully functioning, but you cannot live without a heart fully functioning. I want to make

Dr. Regina Druz (15:09)

That’s what I always say. I say longevity is vascular because you can have the best muscle mass and the best bone mass, but if your heart does not beat, none of it moves. that’s where we are. So very interesting because we look obviously at holistic heart centers. have a lot of patients who are looking for health optimization.

longevity optimization and these are some of the markers you mentioned. And please don’t worry everybody about those chemical names and we will spell them out. You’ll get the full transcript, but we do measure all these markers, markers of protein oxidative stress, DNA oxidative stress, sugar oxidative stress, fat oxidation. oxidation, this rusting on the inside, it’s such a fundamental process that it actually affects

not just one place, but very critical, important places. But, Nayan, you said these are all sort of secondary markers, they’re downstream, right? So what is the primary process that is happening in all of us, as we, know, 30 and beyond, that is aging us? You know, what is that sort of critical, you know, chemical reaction or critical process that is taking place in the body?

that exposes individuals to unhealthy oxidative stress.

Dr. Nayan Patel (16:31)

Well, the unhealthy, so the thing is, stress is there every single day. And you need a little bit of stress every single day because without the stress, you cannot kill all the bacterial growth, or making, getting rid of the zombie cells, or the cellulitic cells, or the old cells. So the oxygen stress is actually necessary. The issue is not about oxidation. This little bit of oxidation is not oxygen stress, it’s oxidation, right? When the thing

Dr. Regina Druz (17:01)

Life important oxidation.

Dr. Nayan Patel (17:03)

Yes,

but the thing is if that increases, that’s to me, that’s oxidative stress because now it’s about beyond because that increase in the oxidation is now is damaging the cells, damaging how we regenerate new cells, how we ⁓ refurbish all the old cells and things like that. And so that oxidative stress to me is the chronic

exposure of all this oxidation that your body cannot neutralize that part. And the thing is I never understood, I never appreciated how hard your body works to create this homeostasis. Because think about it, every single day you go crazy and your body comes back to homeostasis. You go crazy and come back to homeostasis. But as you age, this marker where the benchmark is,

It’s also, when it goes on, it’s also shifting. It’s also shifting. you come back to homeostasis, but it’s shifting towards going towards diseases, going towards something that is irreversible changes in our body. And to me that, I want to stop that from moving forward. Because I want to slow down as low as possible as so much as like,

Dr. Regina Druz (18:17)

You want to slow it down.

Dr. Nayan Patel (18:22)

People went into Tai Chi, the hand movements are so soft and so subtle. I want to do that hand movements that are so subtle that aging literally stops for you, right? But by the time people realize that they need to do that part, I people in their 40s and 50s, which are usually about 15, 20 years late from the first start of the process. So I’m hoping that by listening to you and this conversation that people will take

the information and start if you’re in late 20s, start today. And we have tips for you guys, by the way, how to get this thing done. Because I have spent my whole life trying to figure out how do I get the oxygen down to as low as possible. Because what I’ve learned over my lifetime is that there’s not a single product that existed that actually be oxygen stressed down to zero.

It was never there. I mean, there thousands of products in the marketplace today that claim to be antioxidants, that claim that they bring your stress levels down, but nothing, nothing actually ever did that.

Dr. Regina Druz (19:35)

That’s amazing because you know, so first of all, this process that you’re describing, you know, this is a process of hormesis, right? The body maintains the balance. That’s homeostasis. Hormesis is you, right? So you as an individual, if you get just enough stress to be beneficial for you, like think, for example,

when you exercise at the gym, right? This is stress. It’s stress in cardiovascular system on the muscle, you know, or if you go and do a cold plunge, hey, that’s really stressful, right? But what that does is that the beneficial stressors promote adaptations, and that’s the concept of hormesis. And so, you know, the oxidative stress, when it’s beneficial, when it kills bacteria, old cells, viruses, you cancer cells,

That’s hormesis, right? But if, you know, the adaptive good, good, good, good cleaning out opportunity. But if your hormesis is not there, if the body systems are overwhelmed because the damage is cumulative as we get older. And as you said, Nayan, by the time people in their 40s or 50s, it is mind blowing to see kind of how fast

that aging compounding has taken place, right? And so if that is not addressed, you end up in a situation where there is no more hormesis because instead of these beneficial adaptations, there is further injury. And so it is super common. And you know, the word that is used here, as you said, antioxidants, right? People say, I have oxidative stress, I have…

Another favorite word, inflammation aging, right? This is what oxidative stress usually comes with. know, inflammation aging even sort of gets mentioned as one of the hallmarks of aging. So inflammation aging, right? So let me pile on the antioxidants. So what are the antioxidants from the pharmacist perspective? Tell us what are they doing and what are they not doing?

Dr. Nayan Patel (21:37)

What did I do? So before I answer that question, I want to say one more thing. I just came back from Antarctica. And guess what I did? I did a Polo Plunge. Polo Plunge. was there for, I mean, there was such a big crowd. Everyone wanted to do that part. And so they kind of tie you on a rope so they can pull you back in. Right? was crazy.

Dr. Regina Druz (21:59)

my God, they would need to tie me like into three ropes and I will probably just like dip my toe and say, pull me back in.

Dr. Nayan Patel (22:06)

You know, no, no, I was there. I laid on my back for a little bit too. And then they decided tugging you in. said, ⁓ I want to stay in for a little bit longer. It was so, so refreshing. But you know what? As soon as you come out, your body adapts and you come back to know it. And that energy rush that you get after you come out of the water, because it was was zero degrees. It was absolutely the water was.

Well, zero degrees Celsius, so I think 32 degrees Fahrenheit, but it was just a cold, cold, cold water. But your body adapters really fast, and you get this euphoria experience for like a few seconds to maybe a minute or so. That is what people do for it. Other options, you take antioxidants. So let’s talk about antioxidants, okay? So there are three categories of antioxidants. So I want to tell you all three categories. One.

I put them in a bucket, I’m gonna put it in three different buckets for you. Bucket number one is all the antioxidants, so-called antioxidants that you take from pills or juices and things from outside sources like vitamin C, vitamin E, carnosine, CoQ10, there’s cholera juices and there’s mona V juices and some Amazon Ford juices. I don’t know, there’s so much products out there.

Dr. Regina Druz (23:01)

Okay.

So

you eat them, you ingest them.

Dr. Nayan Patel (23:25)

You

ingest them, you know, take IVs off this vitamin C as well and people do all kinds of things, so-called antioxidants from outside sources. I put them in bucket number one.

Dr. Regina Druz (23:35)

Okay, outside supplied, right? Exogenous antioxidants, like exogenous ketones outside of you. Okay.

Dr. Nayan Patel (23:44)

I’ll tell you. Bucket number two, your body pres endogenously inside the body, some enzymes like glyethion peroxidase, GPX for short, or supraxid, dyspotase, SOD for short, or catalase, or small peptides like carnosine, right? These are what the body produces, and I put them in bucket number two. And the bucket number three is a molecule called glyethion.

Dr. Regina Druz (24:12)

wow, it deserves its own bucket.

Dr. Nayan Patel (24:15)

Its own bucket and the reason is its own bucket is because guess what bucket number three, which is glue a thion is more powerful than bucket number one and two combined Wow, and that’s a very profound statement because you can take all the thousands of products in the world all the ends that the Jibani produces glue that by itself is more powerful and can be also stressed out to zero within seconds with just glue them by itself

Dr. Regina Druz (24:45)

We produce it internally.

Dr. Nayan Patel (24:47)

producing

currently until the last breath. we, body can produce plenty of it as long as it has the three amino acids, glycine, glutamine, cysteine, which is from your diet. You have the two enzymes that the body needs to put this three amino acids together. The body can produce plenty of it. Probably it has ATP energy, which kind of gets lower as you start aging because of mitochondrial ⁓ deficiencies. So ATP and NAD

is an electron transfer molecule. As long as you have all these things available to your body, your body can produce glutathione until the last breath.

Dr. Regina Druz (25:26)

The problem is that when the body gets older and when there are chronic diseases in place and these environmental exposures, the glutathione production sort of like starts to peter down, right?

Dr. Nayan Patel (25:42)

And guess what it starts coming down at? What age? 30. You guessed it right. Why? You see the thing is I had no idea because all the researchers I started looking at, said, hey, 30 is the first time I see it deep in the globe. I it was across all publishers across the globe. And people could figure out why it was 30. Then they started looking at genetic markers, mutations, at the age of 28, 29. And so everything is sort of correlated, right?

In 2029, you start seeing oxidative stress markers. You start seeing reduction of the glyoethyl levels. Everything is about that two or three years. Everything is kind of, it’s picking up the snowball of the, you can never blame a snowflake for an avalanche, but it starts from there, right? It starts from there. So age 2029 is the earliest thing you can start figuring out at that time. said, okay, I got to change my life today.

Don’t wait till 32, today’s the day. If you’re 20, 29, today’s the day. That’s what they say. If you’re a desert and if you’re in a tree, the best time to plant a tree is guess what, 20 years ago.

Dr. Regina Druz (26:52)

Yes, the second best time is now.

Dr. Nayan Patel (26:55)

It’s

today. So if you’re 15, do not sweat it. Start today. If you’re 17, hey, you’re still alive. Start today. It’s okay. It doesn’t really matter.

Dr. Regina Druz (27:06)

I agree with you. So let’s talk about glutathione. Let’s talk about sort of, because you made a couple of really important points, right? And some people right now are going to get upset at us because they might be taking antioxidants. And first of all, we always tell our patients to get on the antioxidant rich diet and it’s still a great way. It’s a baseline. You get a lot of nutrients and their natural forms, including the nutrients that Dr. Nguyen will tell you in a few minutes.

that you will actually use to optimize your glutathione production, right? But a lot of people right now are getting upset because they are taking antioxidants, right? They are sometimes, you know, maybe doing intravenous infusions. And now you come in and you say, forget about all of this. What you really need is glutathione and maybe you’re like 20 years too late, although I give you some hope, right? So what exactly…

what exactly does glutathione do with, know, why is it more impactful than, as you said, you know, the stuff that we take from the outside and even the stuff that we’ve produced on the inside? Why is it more impactful than this?

Dr. Nayan Patel (28:17)

So first of all, the number one antioxidant sold in the world is vitamin C. And if you think about vitamin C as a chemical, it is not an antioxidant. It’s a pro-oxidant. Interesting. Then here’s a question. How does vitamin C actually work as an antioxidant? If you think about it, vitamin C, okay, let me back up a little bit. ⁓ Glutathione.

Dr. Regina Druz (28:44)

pharmacist and you is coming out. Here we go.

Dr. Nayan Patel (28:47)

The gluthion is a reduced form, The active form of gluton is in a reduced form and the reduced form gets oxidized once it’s

Dr. Regina Druz (28:57)

Explain to people please what a reduced form is because you I used to love organic chemistry, but I can’t imagine that, you know, lot of people are like that, you know, so what is a reduced form of something? Like, is it just a smaller form or is it like a special form?

Dr. Nayan Patel (29:13)

It’s a special form. It’s not a smaller form. The reduced form is basically it’s missing a charge on the electron. So that way it can accept the electron from somebody else and get it neutralized. But it doesn’t get neutralized, gets oxidized, so to speak, right?

Dr. Regina Druz (29:28)

That thought because we’re going to bridge the gap right now for our listeners, right? Because it gets a little bit technical. So these reactive oxygen species that we spoke about just maybe whatever 10 minutes ago, ROS, they are not neutral, right? So, you know, in life you could be positive, negative or neutral, right? You could have, you know, positive attitude, negative attitude or neutral attitude. The same as, you know, so for the molecules in our body, reactive oxygen species are actually not neutral.

They are charged, they’re usually negatively charged. And because of that, you know, as most people with negative attitudes, they’re highly reactive. They need to discharge that charge attached to something and just unload all that negative energy, right? Sort of like you when you’re hungry or something like that. you know, so that sort of the analogy, right? So we need to have an antioxidant or a substance.

that could allow this negative charge to be disposed off, right? And so that’s what reduced form actually means because it will get that negative charge, you know, sort of absorbed in and, you know, it will get it neutralized.

Dr. Nayan Patel (30:40)

Yeah, you’re so good at this thing because I’m thinking of a pharmacist’s brain. I’m looking at chemical structures and all those things, but I understand that the people need to understand what is coming from the thing. So gluten actually absorbs all the negative energy from our species. In that process, it gets oxidized. That’s right. gets oxidized. And so two oxidized molecules of gluten comes together and becomes stable so it doesn’t damage your body.

Dr. Regina Druz (30:49)

Exactly what it means.

Dr. Nayan Patel (31:08)

but it’s stable enough that they can circulate power. Now here’s the thing, this oxides form of glutathione, the stable molecule can accept the energy from vitamin C and become reduced again.

Dr. Regina Druz (31:25)

It could recycle. It serves its function, but it could recycle.

Dr. Nayan Patel (31:29)

So vitamin C is actually recycling glucothione, oxidized glucothione, and making it reduced again. So you can go on and pick up lot more energy from this ROH species. So vitamin C is actually not an antioxidant, but it’s allowing the glucothione to recycle and act as an antioxidant. That’s why people always say, low dose of vitamin C is an antioxidant.

and high dose is a pro-oxidant. mean, vitamin C is not that smart of a molecule, trust me, right? It’s not that smart. It is just there to revive oxidized glutathione back to the reduced form. And so I just wanna make sure people understand that part because that’s what the so-called antioxidants are. Now the glutathione by itself, it’s an amazing antioxidant because it can…

quench all these free radicals really, really fast, faster than any other chemicals or any other enzymes in a body that’s been produced. So that’s why glutathione is the most abundant molecule produced in the human body.

Dr. Regina Druz (32:42)

It’s the bullet. it reflects our burden of this reactive oxygen species that we need to do literally, you we probably, you and I are probably quenching them right now as we speak.

Dr. Nayan Patel (32:54)

Yeah, so anyway, so that’s why I have such a high respect for gluothione in the sense that we can’t do that part. But it’s not just taking supplements. I want people to understand just taking supplements is not the answer of gluothione. Right? You’re going to do two or three things before you supplement and that should be your daily lifestyle because I’ll tell you one simple story. I asked my grandpa, I said, grandpa, how do people become rich?

And you know what he said? Rich people have low expenses. I said, what do mean? If you don’t have anything to spend on, guess what? Whatever money you’ve got, you’re rich because you have nothing to spend on. So you got to reduce your expenses. Whatever things that can deplete the gluten levels out of your system, you got to stop doing that. Stop exposing yourself to pollutions, toxic chemicals, smoke.

Oh, that’s, that’s, I’m not gone to that party yet. This is outside environment. Internally, the number one thing is smoke, right? Smoke inhalation is, it defeats the gluten levels. And by the way, one drink of alcohol, one drink can deplete your gluten levels for at least four hours.

Dr. Regina Druz (34:11)

want you to hold that thought because my patients know this and I tell it to them all the time is that alcohol is a toxin, right? It’s not just implications and HL fibrillation and everything else. Alcohol is a toxin. is a toxic substance. And ⁓ whether you believe World Health Organization data or not,

You know, their research had shown that it is a toxin in any amount. So there isn’t a safe amount. It is a socially acceptable toxin, but that’s what it actually is. So one drink depletes glutathione.

Dr. Nayan Patel (34:49)

or four hours. I mean, recently, recently, we just heard the story about alcohol is linked to seven different cancers. I mean, that’s more cancers than smoke inhalation. So if you think about it, it’s yeah, it’s, I don’t care which way you look at it, just because it’s flavored salt. I call alcohol as a solvent because it’s a solvent. And solvent in a chemistry lab is the most toxic products in the whole lab. We have a special ⁓ case.

a metal case labeled poison. In that we store, guess what? Salads. And we drink salads because it’s flavored. said, my.

Dr. Regina Druz (35:29)

And

we wear protective goggles and everything on top. So you said, so three things. So one thing, number one is to reduce these toxic exposures that deplete your glutathione. What is the thing number two?

Dr. Nayan Patel (35:43)

Thing number two, your diet. Your diet should be rich on all the things that necessary to increase the glutine production on your own naturally, because your body can do it. So make sure your diet is a cysteine rich diet. So cysteine is one of those amino acids that is not in everybody’s diet, because these are the stinky foods, right? ⁓ So it might not be in everybody’s diet. So if you just put your favorite search engine or your AI robot, just ask that person, say, hey.

What are the 16 rich foods and you can get your vegan choices, your omnivore, your carnivore, all, I don’t care what diet plan you follow, you’re going to get some choices. Make sure that those foods are in your daily diet plan every single day. And if you just do those two things alone, you can literally sustain your glutathione levels until the age of 35 to 40.

Dr. Regina Druz (36:15)

Bye, Kanye.

Already good extension

Dr. Nayan Patel (36:41)

Yeah, it’s a very good extension. by itself, I mean, you’re thinking about 10 to 15 years of extension of life by just having a proper diet and not exposing to all these toxic chemicals. So to me, that’s the best thing you can do for yourself. And at that point, when everything fails, starting at the age of 35 to 40, and actually in most cases, 99 % of the people are not going to be doing that part, they’re going to start supplementation at the age of 30.

the supplementation is only glutathione. And to me is, okay, glutathione, are thousands of products out there, which one is the best one to use it? And I’ll go into detail about that product solution as well. But supplementation is only necessary and is only beneficial if you combine them with reducing exposure and having proper diet. So you’ve got to have the alternate.

Dr. Regina Druz (37:34)

So that’s so important. You know, I want to emphasize it again, because you you have heard this on the show every single episode, right? Foundation is key. You need to build a foundation because no supplement, no hormone, no peptide, sometimes not even drug will actually do that foundational building part. You’re the one who has to do the foundational building part.

And it’s hard because most of these solutions, they’re not sort of like, ⁓ I’ll spend the day doing it tomorrow and everything will be fine. Most of these solutions require you to change patterns in your life that very often have been longstanding habits. And some of those patterns are actually very difficult to change. I remember, for example, I had a patient who came in because he was ⁓ advised to get a defibrillator.

And he was advised to get a defibrillator because his heart muscle was very weak, call this condition, conditional heart failure. ⁓ He unfortunately was using a little bit too much alcohol. He was depressed. He was also working far away from his primary residence. So he was in traffic two and a half hours, one way each day. So about five hours in traffic every single day, inhaling all the dust, inhaling all the carfumes.

And one of the solutions, the obvious one was to obviously stop his alcohol exposure. One of the solutions was for him to get a small studio by his workplace because he had to continue to be employed for a couple more years to earn his pension and to quit, to get that small studio to cut down on his commute, not only to stop breathing the fumes, but also open up some time when he can have some fresh air, when he can go and exercise.

This patient, you we did a lot of other things obviously, but this patient reversed his heart failure. He never had a need for defibrillator. He basically ended up staying healthy, vital, doing everything that he wanted on a minuscule amount of maintenance drugs, never needing a defibrillator device because his heart recovered. So there is a lot of power to these approaches, to this foundational.

Dr. Nayan Patel (39:52)

It is and I want to make sure people do understand that part that hey We are here to help you but we are God we cannot reverse every single thing that can happen to you and this thing came to me very Clear because I was helping my wife in the kitchen one day cleaning the oven Right. Mm-hmm. one has all this melted cheese on there because yes, we like to cook on their things and it took me literally two hours

to scrub every single thing in the oven. And in two hours, you’d assume it’ll be spotless brand new. Nope. No, it’s never brand new. It’s never brand new. Right? And so I want people to realize that part that we can help you as much as possible, but we cannot reverse every single damage that has happened to your body. So stop damaging in the first place. Prevention is so much better than treating

afterwards. So, yeah, so we can help you, we can get you stabilized and hopefully have a better quality of life, but I would rather prefer that you don’t come to us in the first place because you prevented this problem from the very get-go from happening. And I want to make sure to emphasize that there is a way you can prevent this problem today, provided you stop smoking, stop drinking, a better lifestyle, stop exposing yourself to all these toxic chemicals.

having a proper diet, making sure that those are important, those replace all the things, having a better sleep pattern, having a better exercise routine, having some time to yourself to enjoy all those things. And after all those things, if you’re only 30, I only take one supplement, by the way. I’m not here to gouge any of the companies today because.

Dr. Regina Druz (41:39)

and I know which one it is.

Dr. Nayan Patel (41:41)

Yeah, but I only take one supplement because it’s glutathione and that’s the reason is because That has been such a huge impact Not just in my life, but all my family’s life my my patients life said it you know I deal with all kinds of patients all over the world now and it has it has made a Such a huge impact and I get patients there in the 60s and 70s They have been damaged the whole body and I was able to stabilize them

reverse some of the damages, not of course 100%, nothing’s 100%, but they are able to have a very good quality of life moving forward. And so I’m going to help you save money today.

Dr. Regina Druz (42:21)

So tell people how to choose a glutathione supplement, what they should look for, is there anyone who shouldn’t be using it? Because as always with supplements, sometimes most people are okay with them, but sometimes there are groups of people that may not really benefit or where it could be a little trickier. So how should somebody, people listening to us right now and they’re saying…

I’m going to go get that glutathione for myself, right? That’s what’s going through people’s minds. I know it’s going through my mind. How should people approach that?

Dr. Nayan Patel (42:58)

So I’m going to tell you the history of gluothione now. All right. 140 years ago, gluothione was discovered. It was thought to be the ultimate product that can change the trajectory of how life can be in singularity, which is life in perpetuity forever. That was a thought process 140 years ago that, we can live in perpetuity for the rest of our life now. We will never die if our gluothione levels are optimized at all times. That was a thought process 140 years ago.

140 years Nobody ever figured out how to enhance growth levels inside your body to the highest amount. Nobody figured out, right?

Dr. Regina Druz (43:38)

The solution is there, but we lost the key from that door.

Dr. Nayan Patel (43:42)

Yes. so the thing is, we have in 1999, I made the first liposome, glutathione product in my pharmacy. Liposome is a technology that basically protects the glutathione, doesn’t get broken down. Glutathione is a tripeptide, is a three amino acid chain peptide. So peptides are not proteins, but the body sends them as amino acid chains and they just chop it up and break it apart. Right? Right.

Dr. Regina Druz (44:10)

The stomach just incinerates everything. Yes.

Dr. Nayan Patel (44:14)

and it only absorbs the amino acids out of it. So I thought if I put in liposomes, it will protect from the harshness of the stomach acid and hopefully will absorb it in the intestines. But guess what? It didn’t matter. It did not matter. The liposome forms were being destroyed. The glutamate was not getting absorbed. My glutamate levels are rising. I couldn’t figure out why it was rising in some people, not in everybody. But long story short, it did not work for me.

So I said, this is not going to work for me long term because I need guaranteed results in everybody.

Dr. Regina Druz (44:47)

You need to bypass the stomach.

Dr. Nayan Patel (44:50)

Yes, so that did not work. So secondly, first, secondly, you know what? 2001 come out, I was just going to inject it. So I started making injectable glue with iron. And for 20 years, I’ve been injectable glue with irons. I’ll probably be one of the largest producer in the United States. I mean, if you think about 25 years ago, I was selling it to Las Vegas where people are just getting drunk and think the IV pushes. 25 years ago, it was unheard of it.

People didn’t even think about it. Not today, everybody gets it all the time, but 25 years ago, I was pioneering this whole industry with some physicians trying to get this thing done. It did not work for more than 15, 20 minutes. And I go, why not? Why not? And then I found a research back in 1991 saying that, if you inject lyrithion, it only stays in the plasma, the water part of the blood. It never entered the blood cells, ever.

never enter the blood cells and the plasma gets cleared by the kidneys every five to 15 and everything was in the urine in the five to 15 minutes and so it’s

Dr. Regina Druz (45:50)

Quickly.

So expensive infusions for expensive urine. Yeah.

Dr. Nayan Patel (46:00)

Only for the glutathione. Okay, if you’re doing some other infusions for all the vitamins like magnesiums and calciums and C’s and all those things, go for it. Knock yourself out. But when it comes to glutathione, it did not do the trick. Now, it helped my people that were passed out and have your hangover because…

Dr. Regina Druz (46:19)

in acute situation.

Dr. Nayan Patel (46:21)

problems, it cleared the liver out with alcohol temporarily and give them a chance to survive. And guess what? We put these people back on the streets again, so they’re drinking the second day again and come back. It was just a vicious cycle. don’t recommend it to anybody. please don’t use it. No, not a good choice. So it did not work. So I knew that if I want to have a fighting chance of improving glutathione levels, I have to

penetrate the cell membrane. getting to cell membrane is nearly impossible. has any technology in the world that can penetrate the cell membrane. So to me, this is what I have to crack the code now. So I started research basically back in 2000, 2001, trying to figure out how do we get through cell membranes. And so back then,

There was something there was new emerging polysaccharide sugar types of molecules that were being used to see ⁓ if the the cell membranes can penetrate that part What we found out was on the cell membranes. There’s something called lipid rafts Does therefore sell to cell communication? Now if you think about it if somebody want to transport nutrients all over the body You get into the bloodstream the blood goes all over the body and you get nutrients everywhere in the body

Well, wait a second. There’s something called cell-to-cell transfer and they use lipid wraps to go through that. And so to me, it’s okay. This is a tripe that produced inside the cell membrane by the mitochondria. It’s not in the mitochondria, it’s inside the cell and then it gets transferred into the mitochondria. So said, I need to get inside the cell membrane. If I can get there, it can go from cell to cell transfer all of it. I don’t have to worry about the bloodstream at all.

Dr. Regina Druz (48:09)

You could distribute exactly.

Okay, so tell us how does one get it into a cell membrane?

Dr. Nayan Patel (48:19)

So I got, what I discovered was, I took some bunch of polysaccharide molecules and I got to the cell membrane. I said, the trick part is, how can I take this polysaccharide molecule, which is circling in shape, and stuff glutathione inside? It’s like having a huge beach ball and having a small one inch ring and stuff the beach ball into that ring. It’s impossible. And so that took me seven years to figure out

How do we use protein developing methods? How do we twist the molecules without losing the polarity? All those things. in 2007, making stable, in 2007 was the first year I discovered a way to squeeze this molecule, get in this ring structure, put it inside it, transport it through the skin because skin cells are available to us immediately.

Dr. Regina Druz (48:56)

stable.

Dr. Nayan Patel (49:16)

I can use it in the buccal membrane, but buccal, there’s a lot of enzymes, it will chop it up. The nose was, another choice was a good choice, but nose, the pH was so low, there was literally having some burning sensation, which most people might be okay, but no, it’s not a choice for long-term use. So only cells that were available to me was skin. And oh my God, it was like, I pry over here and boom, it gets to skin.

and the skin transports to the body. ⁓

Dr. Regina Druz (49:48)

It’s one of the, not the largest surface because our largest surface is actually our endothelial surface, but you know, but it’s the second largest surface. That’s amazing. So one could reasonably elevate their levels of glutathione using the transdermal or through the skin application.

Dr. Nayan Patel (50:05)

It’s a topical solution. wish it was transdermal. Transdermal is going through the skin membrane inside your bloodstream. It’s not doing that. It’s taking the skin surface, but there was a research done just about a year ago, was just published, ⁓ of the head of the neurology at NFL did a study where I had no idea because he’s a patient of mine, was just buying the glutathione from me. And so he applied the glutathione and he saw the

brain glutathione levels just spike.

Dr. Regina Druz (50:36)

Interesting. So did he apply actually, do you have to apply it close to the organ that you intend to influence or you can just like do it anywhere in your skin?

Dr. Nayan Patel (50:46)

I think he applied on his arm or his belly and he saw the glutine levels in the brain lit up and it was nothing in the blood. So the body was distributing this. The only expression, as I said earlier, the only expression we have is there’s something called skin cell to cell transfer using the lipid rafts.

Dr. Regina Druz (51:05)

And communication, there’s cell-to-cell communication, which sort of directs it to the right place.

Dr. Nayan Patel (51:12)

And so now this is a recent study that was published. Even though I had seen the results in the past, I couldn’t explain how and why. And so for the very first time, very first time, because here’s the thing, you can inject glutathione, I don’t care, 5,000 milligrams, 10,000 milligrams, and your oxygen stress will never go down to zero. With a topical application.

I can literally get down to zero oxygen stress with only like maybe a couple hundred milligrams.

Dr. Regina Druz (51:45)

Amazing. So how often does one have to apply it though, right? Because as you and I just discussed, know, the damage is cumulative. happens every single day from multiple sources. So is it something that one has to do several times per day, once per day, like sort of what’s on the part of the user, right? What would the user need to do?

Dr. Nayan Patel (52:07)

So I’m going to give you an analogy for a house. If your house is really, really, really dirty.

Dr. Regina Druz (52:14)

I clean all the time.

Dr. Nayan Patel (52:15)

Right what you what you gonna do is you’re gonna clean one section at a time So when it comes to glue a time Slow and steady every single day is what you got to do because if you’re trying to clean the whole house in one day You can have so much reactions because the body’s gonna body’s gonna go into like conservation more it’s gonna be having herc-shimer reactions where you’re have rashes and itching and Headaches and diarrhea people do not understand

Dr. Regina Druz (52:43)

We don’t want those.

Dr. Nayan Patel (52:45)

We don’t, nothing, nothing like that. So slow and steady, four sprays, is about 100 milligrams, twice a day is all you need. And slowly, slowly, slowly start detoxing your body. And it’s not like, okay, let me back up one more time. Glutide is only doing two things for you, by the way. It’s not, it is not this miracle molecule that people think is gonna solve all my problems. It only does two things.

One is it’s an anti-oxidant, that means it quenches all the free radicals, both of oxygen and nitrogen. ⁓

Dr. Regina Druz (53:21)

We haven’t even discussed reactive nitrogen, that’s okay.

Dr. Nayan Patel (53:25)

That’s okay. But nitrogen is essential for our blood pressure and for heart functions. Nitrogen is a very essential gas, but nitrogen reactive species are also damaging to the heart as well. So those have to be quenched and they have to be neutralized. So both oxygen and nitrogen free radical have to be neutralized. That’s one thing. The second that the glutathione does, it aids in the conjugation pathways in your liver where it attaches itself to…

active chemicals or metals and things like that where it can destroy, it gets destroyed in the process, but it can eliminate through your liver once and for all.

Dr. Regina Druz (54:03)

So it’s detoxifier, right? So it’s important for people to understand. That’s what that conjugation process actually means. It’s about liver detox. So not only is it a master antioxidant, it’s also a detoxifier. That’s why when we have a deficiency, it influences so many chronic conditions because both, you know, all of the chronic conditions are, get worse, unfortunately, when the oxidative stress builds up and detoxification.

capacity decreases, right? So that’s sort of like that room for chronic conditions.

Dr. Nayan Patel (54:40)

So those two processes, if they’re taking care of it, imagine the whole human biology now is free to do whatever he wants to do. Because to me, it’s the most important thing in our body is to quench the free radicals and detoxification. When those two things are done, you’re actually unleashing the human potential to do whatever it wants to do. And to prove that,

I did a study, there was a human trial done two years ago at the, it was a medical school in California. It was a three day trial, three days trial. You give glutine twice a day, just 100 milligals is what we talked about, is four sprays twice a day. And for three days, and what they did was they took the blood and in the test tube and infected the blood with mycobacterium infection. Now mycobacterium has no…

No cure at this point, right? There’s no antibiotics, else. So what they said, hey, what could happen, right? Just indulge with me. These are the results. These are very shocking, right? When you apply the glyothione, within one hour, they saw reduction in the oxidative stress markers. Within one hour. So that was proven. And it was not just like five or 10 % or 20 % of the cases. 100 % of the cases.

The MDA levels went down, all of them. Okay? So that was one thing. Then they took the blood out and they put the, in front of the blood, the mycobacterium infection. Of course it was against the placebo. People that have mycobacterium infection, the load of the bacteria went down within four hours. Amazing. The one with the placebo, went up because it was incubating, so it was multiplying. was growing. It was growing.

in the active group it went down and so the professor says, hey, wait a second, this is not antibiotic, how is it helping, how is it working, right?

Dr. Regina Druz (56:43)

It’s

releasing bodies natural, enhancing naturally built pathways and defenses that we were born with. We were born into this world to have these defenses.

Dr. Nayan Patel (56:56)

defend itself. Yeah. And so the defense systems are what? IL-2, IL-12, interferon gamma, TNF alpha, all those immune markers went up. In normal cases, I my God, that’s going to kill you because it’s too much immunity, too much inflammation. But that went up because it was infected with mycobacterium. So it literally reduced the dose down. And so the thing is, we realized that

the body has the capacity to literally fight within hours, within hours to

Dr. Regina Druz (57:33)

It just needs a little help from time to time.

Dr. Nayan Patel (57:37)

So if the body doesn’t have to clean the whole body and if that’s the taking care of it, guess what? It will unleash the potential of ⁓ human behavior or human immune system to literally regenerate, rejuvenate, and basically detoxify your whole body from inside out. And to me, that was the most profound thing I can ever have because as much as I love you Dr. Drews, but trust me, human body can find more problems and fix the problems before

any diagnostic tool that we have in the hospital today can find it.

Dr. Regina Druz (58:10)

That is so true. And I tell it to my listeners all the time because patients often or adults often would say, ⁓ my LDL cholesterol is too high, my ApoB is too high. And I always tell my patients, look at it as a signal. It’s the red flag that your body is waving at you and says, hey, something is wrong with you metabolically. Something is wrong with you with regard to oxidative stress. Maybe you have immune system out of whack.

Maybe you have an infection. This is, you know, hormones out of balance. This is why your LDL all of a sudden is unleashed and it’s climbing, right? You know, so yes, it will damage the arteries, but it’s also is a signal. Nayan, this has been super profound. I learned a ton. So can ⁓ people get this product at Aura Wellness or how do people get, you know, ⁓ glutathione, which they can use top?

Dr. Nayan Patel (59:06)

Two ways, one, we only distribute through healthcare practitioners like yourself. you can have it and they can buy it from you directly or they can buy it through my website, which is oralvalidness.com. Please mention this podcast. Yeah. Or Dr. Drew’s name, or we can jump a link in that part. But keep in mind, this was just in 2007. It took me 14 years before I released this product to the public in 2021.

Dr. Regina Druz (59:12)

sign up ⁓

Drop a link.

Dr. Nayan Patel (59:36)

Because in that 14 years, I had to figure out how much to give you, how often to give you, how long can I give it to you, am I gonna have any issues, am I gonna have results, what kind of results am I gonna get? And please, all my work is in my book, The Glutathione Revolution. If you’re not gonna pick up a copy, trust me, it is not gonna make me rich by all means, but it’s gonna make you so much healthier that it’s absolutely worth that read to at least take your, you need to become the CEO of your own health.

Dr. Regina Druz (1:00:06)

That’s right. And that’s why this podcast is called own your heart house, because this is what I want every single person to do. Own your heart house, own your longevity. It’s up to you. It’s not up to anyone else. This has been super. I will drop all the links in the show notes. I’m just going to say that I’m so glad you didn’t stick with aerospace engineering.

Because if you did, we would not have had this glutathione breakthrough, which is something that is absolutely super powerful and really a longevity benefit, personal benefit that each person can execute on themselves. Thank you so much.

Dr. Nayan Patel (1:00:48)

Thank you, thank you so much.

Dr. Regina Druz (1:00:51)

Thank you for tuning in to Own Your Heart Health with Dr. Regina Trues. This podcast is powered by Holistic Heart Centers. If you enjoy the show, please rate and review us on your favorite podcast platform. To learn more about our services, visit holisticheartcenters.com and subscribe to our YouTube channel. The link is in the show notes. See you next week.

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