with Dr. Phyllis Pobee
Podcast Summary
Your genetics might be the key to lasting weight loss. Dr. Phyllis Pobee knows firsthand how frustrating it can be to do everything “right” and still struggle with weight. In this episode, Dr. Pobee joins Dr. Regina Druz to discuss how genetics for weight loss plays a bigger role than most people realize. Could your genes for weight loss be working against you? And if so, what can you do about it?
From nutritional genetics to hormones like cortisol and estrogen, Dr. Pobee breaks down why weight gain—especially for women over 30—isn’t just about diet and exercise. She shares how understanding your genetic profile can help you make smarter choices about food, exercise, and stress management. They also dig into the rise of weight loss medications like Ozempic and whether they truly solve the problem or just mask deeper imbalances.
This episode challenges the idea that weight loss is simply about willpower. If you’ve ever felt stuck, Dr. Druz and Dr. Pobee’s conversation might be exactly what you need to move forward with a strategy that actually works for your body.
Episode Breakdown:
- 00:00 Introduction
- 03:57 Hormonal Interplay in Weight Management
- 05:11 Estrogen and Heart Disease in Women
- 07:07 Genetic Variations and Hormonal Imbalances
- 08:41 Cortisol and Stress Management
- 10:21 Circadian Rhythm and Eating Habits
- 12:15 Measuring Cortisol Levels
- 17:54 Effective Stress Management Techniques
- 20:47 Testing Cortisol Levels
- 26:00 Hormonal Changes in Perimenopause and Menopause
- 30:56 Estrogen Dominance and Genetic Influence
- 34:00 Caution with Hormone Replacement Therapy
- 37:18 Key Genetic Variations Women Should Know
- 42:19 Overstressing and Its Impact on Weight Loss
- 45:25 Integrative Approach to Weight Loss
- 49:37 Polygenic Risk Scores in Clinical Applications
Listen to the Audio
Links
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